Alliance for Pandemic Preparedness

June 15, 2021

Allergic Symptoms after mRNA COVID-19 Vaccination and Risk of Incomplete Vaccination

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  • Self-reported allergic symptoms following the first dose of a COVID-19 mRNA vaccine was associated with a 5-fold increase in odds of not completing the second dose after adjusting for demographics, vaccine manufacturer, wave of vaccine eligibility, and other confounders in a prospective cohort of healthcare employees in Boston. Among 61,057 employees who received a first dose, incomplete vaccination occurred in 3% (43 of 1,261) of those who self-reporting allergic symptoms compared to 0.6% of those who did not report allergic symptoms. Self-reported severe allergic symptoms were rare (n=6) and associated with markedly increased odds of not completing the vaccination course (aOR=23).

Robinson et al. (June 11, 2021). Allergic Symptoms after mRNA COVID-19 Vaccination and Risk of Incomplete Vaccination. The Journal of Allergy and Clinical Immunology: In Practice. https://doi.org/10.1016/j.jaip.2021.05.031