June 15, 2021

Naturally Enhanced Neutralizing Breadth against SARS-CoV-2 One Year after Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccine effectiveness, vaccines

• 82% of individuals recovered from COVID-19 maintained RBD-specific IgG titers, RBD-specific B cells, and neutralizing activities between 6-12 months after infection, according to analysis of 68 recovered individuals, suggesting long-lived immunity to COVID-19. In 41% of participants who received an mRNA vaccine, vaccination increased IgG responses by 30-fold, neutralizing activity by 50-fold, and circulating number of memory B cells by 9-fold. Sera from vaccinated individuals also showed robust neutralizing activity against variants of concern and neutralization breadth (the ability to neutralize a diverse panel of viruses) increased over time.

Wang et al. (June 14, 2021). Naturally Enhanced Neutralizing Breadth against SARS-CoV-2 One Year after Infection. Nature. https://doi.org/10.1038/s41586-021-03696-9