June 15, 2021

SARS-CoV -2 Antibody Persistence in COVID-19 Convalescent Plasma Donors: Dependency on Assay Format and Applicability to Serosurveillance

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): immunity

• SARS-CoV-2 antibody responses were shown to increase over time in a study of plasma collected up to 63-129 days following symptom resolution from 18 patients recovered from COVID-19 when using direct double Ag-sandwich assays (Ortho Total Ig and Roche Total Ig). By contrast, measurements from indirect binding assays showed a declining antibody response. Due to their stability over time, the authors suggest using direct double sandwich assays for serosurveillance studies.

Di Germanio et al. (June 14, 2021). SARS-CoV -2 Antibody Persistence in COVID-19 Convalescent Plasma Donors: Dependency on Assay Format and Applicability to Serosurveillance. Transfusion. https://doi.org/10.1111/trf.16555