May 27, 2021

Standardised Quantitative Neutralisation Responses to SARS-CoV-2 Variants of Concern by Convalescent Anti-Sera from First Wave Infections of UK Health Care Workers and Patients

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, variants

• [Pre-print, not peer-reviewed] Neutralizing activity of convalescent plasma collected from patients and healthcare workers infected during the first wave of the COVID-19 pandemic between July and September 2020 (n=61) was reduced by 2-fold against the B.1.1.7 variant and by 8-fold against the B.1.351 and P.1 variant compared to the parent B.1 strain. Neutralizing activity correlated with disease severity. Plasma collected from patients, who generally reported more severe disease courses, had 16-fold and 45-fold higher neutralizing levels against the B.1.1.7 variant and B.1.351 variant, respectively, compared to plasma from healthcare workers, who generally scored low on the WHO symptom severity score.

Cantoni et al. (May 26, 2021). Standardised Quantitative Neutralisation Responses to SARS-CoV-2 Variants of Concern by Convalescent Anti-Sera from First Wave Infections of UK Health Care Workers and Patients. Pre-print downloaded May 27 from https://doi.org/10.1101/2021.05.24.21257729