June 1, 2021

The Indirect Effect of MRNA-Based Covid-19 Vaccination on Unvaccinated Household Members

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccination

• [Pre-print, not peer-reviewed] Incidence of PCR-confirmed SARS-CoV-2 infection was 43% lower among unvaccinated spouses of healthcare workers (HCWs) vaccinated with mRNA vaccines (Pfizer-BioNTech and Moderna) 10 weeks after the first dose compared to spouses of unvaccinated HCWs, according to an analysis of national-level administrative data in Finland. The authors suggest that the vaccines may confer protection unvaccinated household members by reducing transmission from those who are vaccinated. Estimated direct vaccine effectiveness was 69% when comparing incidence of PCR-confirmed SARS-CoV-2 infection of vaccinated HCWs 10 weeks after the first dose with unvaccinated HCWs.

Salo et al. (May 29, 2021). The Indirect Effect of MRNA-Based Covid-19 Vaccination on Unvaccinated Household Members. Pre-print downloaded Jun 1 from https://doi.org/10.1101/2021.05.27.21257896