Alliance for Pandemic Preparedness

June 7, 2021

Marked Increase in Avidity of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Antibodies 7-8 Months after Infection Is Not Diminished in Old Age

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  • A study assessing the avidity, or binding strength, of IgG among 217 participants in Austria soon after SARS-CoV-2 infection and 7-8 months later found that avidity increased from 18% to 42% and did not diminish among older participants. High avidity was associated with a residual neutralization capacity in 97% of participants (211/217). The authors suggest that robust immunity may persist for 7-8 months after infection and is not impaired in older individuals. 

Pichler et al. (June 2021). Marked Increase in Avidity of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Antibodies 7-8 Months after Infection Is Not Diminished in Old Age. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiab300