June 7, 2021

Plasma ACE2 Predicts Outcome of COVID-19 in Hospitalized Patients

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Among patients with COVID-19 (n=306), high plasma levels of angiotensin converting enzyme 2 (ACE2) at hospital admission were associated with increased illness severity within 28 days (OR = 1.8), and plasma ACE2 was significantly higher among patients with hypertension. Circulating ACE2 was also significantly higher in patients with COVID-19 with pre-existing heart conditions and kidney disease. The authors suggest that ACE2 may predict COVID-19 disease outcome.

Kragstrup et al. (June 4, 2021). Plasma ACE2 Predicts Outcome of COVID-19 in Hospitalized Patients. PLOS ONE. https://doi.org/10.1371/journal.pone.0252799