Alliance for Pandemic Preparedness

June 8, 2021

Improved Diagnosis of SARS-CoV-2 by Using Nucleoprotein and Spike Protein Fragment 2 in Quantitative Dual ELISA Tests

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  • A combination of two quantitative ELISA assays using SARS-CoV-2 nucleocapsid (N) and spike subunit 2 (S2) was able to detect at least 10% more true positive COVID-19 cases compared to a commercially available antibody test (Abbott) when tested against a panel of 42 SARS-CoV-2 positive serum samples and 37 negative control samples. Analysis of assay results showed that S2-specific antibody activity specific was weaker and also declined more rapidly.

Verissimo et al. (June 8, 2021). Improved Diagnosis of SARS-CoV-2 by Using Nucleoprotein and Spike Protein Fragment 2 in Quantitative Dual ELISA Tests. Epidemiology and Infection. https://doi.org/10.1017/S0950268821001308