Alliance for Pandemic Preparedness

September 30, 2020

Reliability of Serological Tests for COVID-19: Comparison of Three Immunochromatography Test Kits for SARS-CoV-2 Antibodies

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  • Three commercially available serological test kits using immunochromatography (Hangzhou AllTest, SD BIOSENSOR, and Vazyme) were evaluated using identical sample sets consisting of 99 serum samples from SARS-CoV-2 positive patients and 100 serum samples from healthy volunteers in 2017. All test kits achieved >97% specificity for IgM and IgG and >97% sensitivity to IgG at 13 days after symptom onset. Sensitivity to IgM after 4 days varied, with both Hangzhou and Vazyme unable to achieve values >33.3%.

Fujigaki et al. (Sept 29, 2020). Reliability of Serological Tests for COVID-19: Comparison of Three Immunochromatography Test Kits for SARS-CoV-2 Antibodies. Heliyon. https://doi.org/10.1016/j.heliyon.2020.e04929