October 1, 2020

Expression of SARS-CoV-2 Entry Receptors in the Respiratory Tract of Healthy Individuals, Smokers and Asthmatics

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Using publicly available microarray datasets, Matusiak and Schürch reported different protein expression of SARS-CoV-2 entry receptors and cofactors ACE2, TMPRSS2, BSG (CD147) and FURIN among various airway tissue types between smokers vs. non-smokers, and between people with asthma vs. healthy controls. These findings warrant further studies to use larger numbers of samples from multiple donor cohorts and more antibodies to better delineate the cellular subsets expressing these SARS-CoV-2 entry receptors and cofactors.

Matusiak and Schürch. (Sept 29, 2020). Expression of SARS-CoV-2 Entry Receptors in the Respiratory Tract of Healthy Individuals, Smokers and Asthmatics. Respiratory Research. https://doi.org/10.1186/s12931-020-01521-x