October 1, 2020

Recent Endemic Coronavirus Infection Is Associated with Less Severe COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): immunity

• Pre-existing immune responses against endemic human coronaviruses (eCoVs), which are etiologic agents for the “common cold” that share extensive sequence homology with SARS-CoV-2, may mitigate disease manifestations from SARS-CoV-2 infection. A study among 252 patients with a COVID-19 related hospitalization reported lower risk of ICU admission (OR=0.1) and death (HR=0.3) among patients with eCoV antibodies than among patients without them.

Sagar et al. (Sept 30, 2020). Recent Endemic Coronavirus Infection Is Associated with Less Severe COVID-19. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI143380