October 5, 2020

Use of Hydroxychloroquine and Chloroquine in COVID-19: How Good Is the Quality of Randomized Controlled Trials?

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• A review of 16 clinical trials of hydroxychloroquine and chloroquine to treat COVID-19, of which 14 were randomized, reported concerns about the ability to derive meaningful results from the trials due to the assessed risk of bias in the studies. None of the trials met the CONSORT criteria in full for reporting harms data. None of the trials had an overall ‘low’ risk of bias, while four of the trials had ‘high’, ‘critical’, and ‘serious’ risk of bias assessed by the Cochrane risk-of-bias tools.

Mazhar et al. (Sept 24, 2020). Use of Hydroxychloroquine and Chloroquine in COVID-19: How Good Is the Quality of Randomized Controlled Trials? International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2020.09.1470