Alliance for Pandemic Preparedness

December 23, 2020

Changes in UK Hospital Mortality in the First Wave of COVID-19 the ISARIC WHO Clinical Characterisation Protocol Prospective Multicentre Observational Cohort Study

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[pre-print; not peer-reviewed] Among people recently admitted to the hospital with COVID-19 in the United Kingdom, there was a 19% reduction in the odds of mortality compared to the first wave of the epidemic. After adjusting for demographics, comorbidities, and illness severity, the authors compared the mortality observed during a four-week interval in March to a similar interval in August. They estimate that 22% of the observed reduction in mortality was mediated by changes in clinical practice, with an increasing proportion of non-invasive ventilation and increasing use of steroids. The fall in mortality was also partly accounted for by changes in case mix and illness severity and mortality remained consistently high among people who required invasive mechanical ventilation.

 Docherty et al. (Dec 22, 2020). Changes in UK Hospital Mortality in the First Wave of COVID-19 the ISARIC WHO Clinical Characterisation Protocol Prospective Multicentre Observational Cohort Study. Pre-print downloaded Dec 23 from https://doi.org/10.1101/2020.12.19.20248559