January 7, 2021

A Longitudinal Study of SARS-CoV-2-Infected Patients Reveals a High Correlation between Neutralizing Antibodies and COVID-19 Severity

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

Serum samples from a cohort of 140 SARS-CoV-2 positive patients suggest that increasing symptom severity is correlated with higher neutralizing antibody (nAb) titers. Only 1 of 44 patients admitted to the ICU did not develop a nAb response by the time of sampling, while nAb response was more heterogenous and less frequently observed among hospitalized non-ICU patients and outpatients. Further analysis of the serum samples also showed an absence of cross-reactivity to other coronaviruses, and no effect of the D614G mutation on neutralization activity.

Legros et al. (Jan 6, 2021). A Longitudinal Study of SARS-CoV-2-Infected Patients Reveals a High Correlation between Neutralizing Antibodies and COVID-19 Severity. Cellular & Molecular Immunology. https://doi.org/10.1038/s41423-020-00588-2