Alliance for Pandemic Preparedness

January 25, 2021

MRNA-1273 Vaccine Induces Neutralizing Antibodies against Spike Mutants from Global SARS-CoV-2 Variants

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[Pre-print, not peer-reviewed] Sera from human subjects or non-human primates (NHPs) that received the mRNA-1273 (Moderna) vaccine showed no significant reduction in neutralization activity against the SARS-CoV-2 B.1.1.7 variant emerging from the UK, but reduced activity against the B.1.351 variant emerging from South Africa. The study used two pseudovirus neutralization assays expressing spike proteins of different SARS-CoV-2 variants, and found that pseudoviruses with spike containing K417N-E484K-N501Y-D614G and full B.1.351 mutations resulted in 2.7 and 6.4-fold geometric mean titer (GMT) reduction, respectively, when compared to the D614G pseudovirus. The GMT of these human sera to the full B.1.351 spike variant was 1/290; all evaluated sera were able to fully neutralize. 

Wu et al. (Jan 25, 2021). MRNA-1273 Vaccine Induces Neutralizing Antibodies against Spike Mutants from Global SARS-CoV-2 Variants. Pre-print downloaded Jan 25 from https://doi.org/10.1101/2021.01.25.427948