Alliance for Pandemic Preparedness

February 16, 2021

Reports of Anaphylaxis After Receipt of MRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021

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The CDC identified 66 reports of anaphylaxis from the Vaccine Adverse Event Reporting System (VAERS) during December 14, 2020 to January 18, 2021 (47 cases out of nearly 10 million Pfizer vaccine doses and 19 cases out of nearly 7.6 million Moderna vaccine doses). All cases were treated in healthcare settings, and no deaths from anaphylaxis after vaccination with either vaccine were reported. CDC physician reviewers concluded that the clinical characteristics of anaphylaxis cases following both vaccines were similar. 32% (22 of 66) of case reports noted prior episodes of anaphylaxis from other exposures, including other vaccines, drugs, or food. [EDITORIAL NOTE: This article includes updated results of analyses summarized in the Lit Rep on January 2 and January 22, 2021.]

Shimabukuro et al. (Feb 12, 2021). Reports of Anaphylaxis After Receipt of MRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021. JAMA. https://doi.org/10.1001/jama.2021.1967