February 17, 2021
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial
Category: Article Summary
Topic: Testing and Treatment
Keywords (Tags): treatment
A randomized clinical trial involving 240 patients hospitalized with moderate to severe COVID-19 found that compared with placebo, a single dose (200,000 IU) of vitamin D3 did not significantly reduce length of hospital stay (HR = 1.07). The difference between the vitamin D3 group and the placebo group was not significant for in-hospital mortality (8% vs 5%), admission to the intensive care unit (16% vs 21%), or need for mechanical ventilation (8% vs 14%). No adverse events were recorded, but an episode of vomiting was associated with the intervention.
Murai et al. (Feb 17, 2021). Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2776738