March 1, 2021

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• A meta-analysis of randomized clinical trials comparing patients with COVID-19 treated with convalescent plasma versus control did not detect any significant differences in all-cause mortality, length of hospital stay, mechanical ventilation use, clinical improvement, or clinical deterioration. Results from 4 published, peer-reviewed RCTs including 1,060 patients indicated that the risk ratio for mortality was 0.93. After adding 6 unpublished randomized clinical trials and 10,722 patients to the analysis, the risk ratio for mortality was 1.02. Neither of these associations were significant, and the certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.

Janiaud et al. (Feb 26, 2021). Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19. JAMA. https://doi.org/10.1001/jama.2021.2747