March 3, 2021

Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, variants

• [Pre-print, not peer-reviewed] Reduced neutralization titers against the P.1 SARS-CoV-2 variant were found in both convalescent plasma (6.5-fold) and plasma from individuals who received an mRNA vaccine (2.2-2.8-fold). The P.1 variant completely resisted neutralization by multiple neutralizing monoclonal antibodies. Using a VSV-based SARS-CoV-2 pseudovirus with all 10 mutations of the P.1 variant, the authors note that the magnitude of the loss of activity from vaccinated individuals against this variant was modest relative to that observed with the B.1.351 variant. 

Wang et al. (Mar 2, 2021). Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2021.03.01.433466