Alliance for Pandemic Preparedness

May 1, 2020

High Frequency of SARS-CoV-2 RNAemia and Association with Severe Disease

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  • Detection of SARS-CoV-2 RNA in the blood is associated with poor clinical outcomes and increased mortality among COVID-19 patients. In this study, SARS-CoV-2 RNA was detected in 33% (28/85) of patients, the majority of whom were hospitalized (22/28). Detection of RNA occurred more frequently in individuals who required an ICU transfer (32% v 14%; p=0.05), mechanical ventilation (21% v 4%, p-value = 0.01) and 30-day all-cause mortality (14 % v 0%, p-value = 0.01). Levels of viral RNA in the nasopharynx were not associated with detected SARS-CoV-2 RNA.

Hogan et al. (May 1, 2020). High Frequency of SARS-CoV-2 RNAemia and Association with Severe Disease. Pre-print downloaded May 1 from https://doi.org/10.1101/2020.04.26.20080101