Alliance for Pandemic Preparedness

March 17, 2021

Associations of the BNT162b2 COVID-19 Vaccine Effectiveness with Patient Age and Comorbidities

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  • [Pre-print, not peer-reviewed] Effectiveness of the Pfizer-BioNTech vaccine gradually increased starting at 12 days after the first vaccine dose and then plateaued around 35 days, according to an analysis of electronic health records from 1.79 million individuals in Israel. This period of maximum effectiveness corresponds to a period 2-weeks after the scheduled administration of the second dose and resulted in 91.2% efficacy for prevention of all infections and 99.3% for prevention of symptomatic infections. Effectiveness declined with age and for patients with type 2 diabetes and effectiveness was the same for men and women.

Yelin et al. (Mar 17, 2021). Associations of the BNT162b2 COVID-19 Vaccine Effectiveness with Patient Age and Comorbidities. Pre-print downloaded Mar 17 from https://doi.org/10.1101/2021.03.16.21253686