September 4, 2020

Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: A Systematic Review and Meta-Analysis

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• A meta-analysis of 12 observational and 3 randomized trials found that the efficacy of chloroquine and hydroxychloroquine was inconsistent across the studies. There was no significant reduction in mortality with hydroxychloroquine use (RR=0.98, 95% CI: 0.66-1.46), and there was a higher risk of ECG abnormalities /arrhythmia associated with hydroxychloroquine/chloroquine use (RR=1.46, 95% CI: 1.04-2.06).

Elavarasi et al. (Sept 3, 2020). Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: A Systematic Review and Meta-Analysis. Journal of General Internal Medicine. https://doi.org/10.1007/s11606-020-06146-w