Alliance for Pandemic Preparedness

March 25, 2021

Emergence of the E484K Mutation in SARS-CoV-2 Lineage B.1.1.220 in Upstate New York

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  • [Pre-print, not peer-reviewed] A novel SARS-CoV-2 variant (assigned name B.1.1.220) was detected by ongoing surveillance in samples collected in early February in four patients in upstate New York. B.1.1.220 was characterized with the E484K substitution in the spike protein, also present in the B.1.351 variant that was first described in South Africa and the P.1 variant that was first described in Brazil, along with four other amino acid substitutions. A search of online databases identified 12 other B.1.1.220 samples, all of which were detected in New York since December 2020.

Lesho et al. (Mar 23, 2021). Emergence of the E484K Mutation in SARS-CoV-2 Lineage B.1.1.220 in Upstate New York. Pre-print downloaded Mar 25 from https://doi.org/10.1101/2021.03.11.21253231