July 9, 2020

Systematic Review with Meta-Analysis: Liver Manifestations and Outcomes in COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

• A systematic review and meta-analysis (107 studies, 20,874 COVID-19 patients) shows that the severity of elevated liver chemistries is associated with the outcome of COVID-19; however, the presence of chronic liver disease does not alter the outcome of COVID-19. COVID-19 patients with elevated liver chemistries had increased risk of mortality (OR=3.46; 95%CI 2.42-4.95) and severe disease (OR=2.87; 95%CI 2.29-3.6) compared to patients without elevated liver chemistries. Chronic liver disease was not associated with developing severe COVID-19 (OR=0.81 (95% CI 0.31-2.09). 

Kulkarni et al. (July 8, 2020). Systematic Review with Meta-Analysis: Liver Manifestations and Outcomes in COVID-19. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.15916