Alliance for Pandemic Preparedness

July 17, 2020

SARS-CoV-2 Infection Induces Robust Neutralizing Antibody Responses That Are Stable for at Least Three Months

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  • [pre-print, not peer-reviewed] Among over 50,000 individuals with confirmed or suspected SARS-CoV-2 infection or exposure to someone with COVID-19, nearly 20,000 individuals had detectable antibodies. Of those who were antibody positive, 22% had moderate and 71% had high titers for anti-spike antibodies. Approximately half of the samples with low titers were able to neutralize virus, versus 90% and 100% of the samples with moderate and high titers, respectively. Among 121 donors selected for repeat titers (at a mean of 82 days post symptom onset), there was a slight drop in mean titer among those with high titers, while titers increased among those with initially low to moderate titers.  

Wajnberg et al. (July 17, 2020). SARS-CoV-2 Infection Induces Robust Neutralizing Antibody Responses That Are Stable for at Least Three Months. Pre-print downloaded July 17 from https://doi.org/10.1101/2020.07.14.20151126