Alliance for Pandemic Preparedness

April 6, 2021

Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic

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  • Peaks in the incidence of multisystem inflammatory syndrome in children (MIS-C) occurred 2-5 weeks after peaks in the incidence of COVID-19 and clinical manifestations of MIS-C varied by age. These findings were based on a cross-sectional study of 1,733 patients with MIS-C in the United States. Children age 0-4 had the lowest proportion of severe manifestations, whereas patients aged 18-20 had the highest proportion with myocarditis, pneumonia, and acute respiratory distress syndrome. A higher proportion of older adolescents reported a preceding COVID-19-like illness. Less than 30% of patients reported respiratory symptoms such as cough, shortness of breath, or chest pain.

Belay et al. (Apr 6, 2021). Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2021.0630