April 15, 2021

SARS-CoV-2 Antibody Response in Persons with Past Natural Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

• Vaccine-elicited neutralizing antibody geometric mean titers (GMT) among healthcare workers who received the first dose of the Pfizer-BioNTech vaccine 1-2 months, 2-3 months, and more than 3 months after a prior SARS-CoV-2 infection were 437, 559, and 694 arbitrary units/mL, respectively. In contrast, healthcare workers with no prior infection had a GMT of 118 units/mL after receiving the second dose, consistent with other studies. The findings from this cohort study (n=100; 38 with prior infection) indicate a higher neutralizing antibody response when the vaccine was administered more than 3 months after infection.

Anichini et al. (Apr 14, 2021). SARS-CoV-2 Antibody Response in Persons with Past Natural Infection. New England Journal of Medicine. https://doi.org/10.1056/NEJMc2103825