April 20, 2021

Serological Investigation of Asymptomatic Cases of SARS-CoV-2 Infection Reveals Weak and Declining Antibody Responses

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, asymptomatic infection, immunity

• SARS-CoV-2 anti-nucleocapsid IgM antibodies were detected in a small proportion (6%) of asymptomatic food workers (n=508) in Wuhan in April 2020. In a follow-up survey among 21 of seropositive participants, IgM levels had declined by up to 50% in 90% of individuals. In comparison to a cohort of symptomatic patients 2 months after infection, asymptomatic individuals had lower IgM and IgG-RBD and memory B cell levels at a similar time point after infection.

Yang et al. (Apr 19, 2021). Serological Investigation of Asymptomatic Cases of SARS-CoV-2 Infection Reveals Weak and Declining Antibody Responses. Emerging Microbes & Infections. https://doi.org/10.1080/22221751.2021.1919032