April 28, 2021

Age-Dependent Immune Response to the Biontech/Pfizer BNT162b2 COVID-19 Vaccination

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccination

• A cohort study in Germany determined that antibody titers were significantly lower in adults over age 80 (n=83) vaccinated with the Pfizer-BioNTech vaccine compared to vaccinated individuals under age 60 (n = 93) after one and two doses of the Pfizer-BioNTech vaccine. Most participants in both groups produced IgG antibodies. The magnitude of increase of antibody levels after the second dose was higher in elderly participants, but the absolute mean titers remained lower than in the younger group. After the second vaccination, 31.3% of the older participants had no detectable neutralizing antibodies whereas only 2.2% of participants <60 had no detectable neutralizing antibodies.

Müller et al. (Apr 27, 2021). Age-Dependent Immune Response to the Biontech/Pfizer BNT162b2 COVID-19 Vaccination. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab381