May 10, 2021

Vaccination Boosts Naturally Enhanced Neutralizing Breadth to SARS-CoV-2 One Year after Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, variants

• [Pre-print, not peer-reviewed] Among 63 COVID-19 convalescent individuals assessed at 1.3, 6.2 and 12 months after infection, antibody reactivity to the receptor binding domain (RBD), neutralizing activity, and the number of RBD-specific memory B cells remained relatively stable from 6 to 12 months in those who had not been vaccinated. Among the 41% of the cohort who received an mRNA vaccine, all components of the humoral response were increased, and serum neutralizing activity against variants of concern was comparable to or greater than the original strain achieved by vaccination of individuals not previously infected. The authors argue that immunity among convalescent individuals may be long lasting, and that those who receive mRNA vaccines will produce antibodies and memory B cells that may be protective against circulating SARS-CoV-2 variants.

Wang et al. (May 9, 2021). Vaccination Boosts Naturally Enhanced Neutralizing Breadth to SARS-CoV-2 One Year after Infection. Pre-print downloaded May 10 from https://doi.org/10.1101/2021.05.07.443175