May 24, 2021

Single Dose of BNT162b2 MRNA Vaccine against SARS-CoV-2 Induces High Frequency of Neutralising Antibody and Polyfunctional T-Cell Responses in Patients with Myeloproliferative Neoplasms

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Among 21 patients with myeloproliferative neoplasms (MPN), conditions in which the body overproduces blood cells, one dose of the Pfizer-BioNTech vaccine resulted in a positive anti-S IgG ELISA among 76% (n = 16) of patients, neutralizing antibodies in 86% (n = 18) of patients, and a memory T cell response in 80% of patients following vaccination, indicating response rates similar to those observed among the general population. The authors highlight the need for other studies to assess responses after a second dose, as well as after immunization with the other available SARS-CoV-2 vaccines.

Harrington et al. (May 22, 2021). Single Dose of BNT162b2 MRNA Vaccine against SARS-CoV-2 Induces High Frequency of Neutralising Antibody and Polyfunctional T-Cell Responses in Patients with Myeloproliferative Neoplasms. Leukemia. https://doi.org/10.1038/s41375-021-01300-7