October 12, 2020
Global Projections of Potential Lives Saved from COVID-19 through Universal Mask Use
[Pre-print, not peer reviewed] An IHME analysis found that universal mask use could lead to a reduction of 815,600 (95% UI 430,600 – 1,491,000) deaths from COVID-19 globally between August 26th 2020 and January 1st 2021. The analysis used meta-regression of 40 studies measuring the impact of mask use on respiratory viral infections, as well…
COVID-19 Literature Situation Report Oct. 12, 2020
More than 815,000 deaths due to COVID-19 globally could be prevented by universal mask use between August 26, 2020 and January 1, 2021, based on recent IHME projections
Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19
Among 86 pregnant and postpartum women with severe COVID-19 who received compassionate use of remdesivir, recovery rates were high (93% for pregnant women and 89% for postpartum women) and there were few serious adverse events (16% of all participants). At the beginning of treatment with remdesivir, 40% of pregnant women required invasive ventilation, compared to…
October 9, 2020
Factors Influencing Risk for COVID-19 Exposure Among Young Adults Aged 18–23 Years — Winnebago County, Wisconsin, March–July 2020
Among young adults in one county in Wisconsin, perceived low severity of disease, perceived responsibility to others, peer pressure, and exposure to misinformation regarding masks were identified as drivers of behaviors that might impact risk of COVID-19 exposure. The authors suggest that behavior change messages that highlight both personal responsibility and responsibility to protect others…
SARS-CoV-2 Exposure, Symptoms and Seroprevalence in Healthcare Workers in Sweden
An assessment of the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms, and occupational exposure to SARS-CoV-2 among 2,149 healthcare workers at a hospital in Sweden found that 19% had IgG antibodies against SARS-CoV-2, which was higher than the regional seroprevalence during that time period. Seroprevalence was associated with a loss of smell (OR=28.4), loss of taste…
Neuropathology of Patients with COVID-19 in Germany: A Post-Mortem Case Series
A study of brain tissue from patients who died from COVID-19 indicated that 79% had pronounced neuroinflammatory changes in the brainstem and cerebellum, though in general, neuropathological changes seemed to be mild in most patients. SARS-CoV-2 was detected in 53% of the patients’ brains, and the study found no evidence for central nervous system damage…
Prevalence and Outcome of COVID-19 Infection in Cancer Patients: A National Veterans Affairs Study
The pre-existence of cancer may affects both susceptibility to COVID-19 infection and outcomes, according to an analysis of healthcare records from the US Veterans Affairs healthcare system. The overall COVID-19 attributable mortality in patients with cancer was 10%, which was higher with older age, a higher Charlson comorbidity score, and certain types of cancer. The…
Follow-up of Adults with Non-Critical COVID-19 Two Months after Symptoms’ Onset
Two-thirds of adults with non-critical COVID-19 experienced persisting symptoms up to 2 months after initial onset, with symptoms including loss of taste or smell, difficulty breathing, and fatigue. In an observational study of 150 patients with mild or moderate COVID-19, persisting symptoms at 60 days were significantly more common among those age 40 to 60…
Characteristics of Hospitalized Children With SARS-CoV-2 in the New York City Metropolitan Area
Children with comorbidities who were hospitalized with SARS-CoV-2 were at increased risk for critical care admission and/or need for respiratory support, based on results from a multicenter, retrospective cohort study at four hospitals in the New York City metropolitan area. Obesity was the most commonly observed risk factor for critical care (63% vs. 28%), while…
Antibody Responses after COVID-19 Infection in Patients Who Are Mildly Symptomatic or Asymptomatic in Bangladesh
A study of antibody responses after COVID-19 infection in patients in Bangladesh indicated that while people who had mild symptoms generated an immune response, those who had no symptoms had lower antibody levels or did not generate any detectable immune response. IgM and IgA responses developed by day 14 after confirmation of infection in 72%…
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