Article Summary
January 13, 2021
Impact of Residential Neighborhood and Race/Ethnicity on Outcomes of Hospitalized Patients with COVID-19 in the Bronx
[Pre-print, not peer-reviewed] A single center retrospective observational cohort study of SARS-CoV-2-positive adult residents (n = 977) of the Bronx hospitalized between March-May 2020 found that residing in the South Bronx (OR=1.8), age > 60 years (OR=2.5) and critical COVID-19 (OR=14.6) were significantly associated with mortality. There was no observed difference in 30-day mortality by…
Diarrhea Is Associated with Increased Severity of Disease in COVID-19: Systemic Review and Meta-analysis
A systematic review and meta-analysis (n = 38 studies, 8,407 patients) of COVID-19 gastrointestinal symptoms found that 16% of all patients had at least one GI symptom. The pooled prevalence of nausea/vomiting was 8% and diarrhea was 12%. Patients with diarrhea as one of their presenting symptoms were more likely to have severe disease (OR=1.63)….
Clinical Outcomes and Inflammatory Markers by HIV Serostatus and Viral Suppression in a Large Cohort of Patients Hospitalized With COVID-19
A retrospective cohort study of 4,613 patients positive for SARS-CoV-2 admitted to a hospital in New York City between March 10 and May 11, 2020 found that people living with HIV had increased risk of intubation (aHR=1.73) but similar rates of acute kidney injury and in-hospital death as those without HIV. Most patients were either…
COVID-19 Trends Among Persons Aged 0 – 24 Years — United States
COVID-19 cases in children, adolescents, and young adults increased since summer 2020, with weekly incidence higher in each successively increasing age group. During March 1–December 12, 2020, a total of 2,871,828 laboratory-confirmed cases of COVID-19 in young people aged 0–24 years were reported in the United States, with the majority (57%) occurring among those aged…
Predictors of COVID-19 Vaccine Hesitancy Socio-Demographics Co-Morbidity and Past Racial Discrimination
[Pre-print, not peer-reviewed] A cross-sectional online survey of US adults (n=2,650) conducted between Dec 13 and 23, 2020 found that respondents who reported experiences of racial discrimination had 21% increased odds of higher vaccine hesitancy compared to those who did not report such experience. Vaccine hesitancy was measured using a scale ranging from 1 (low…
Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-through Community Testing Site in Massachusetts
[Pre-print, not peer-reviewed] An evaluation of the Abbott BinaxNOW COVID-19 Ag Card in a drive-through community testing site in Massachusetts using anterior nasal swab RT-PCR for clinical testing found that BinaxNOW had very high specificity in both adults and children (100% for both) and very high sensitivity in newly symptomatic adults (96.5% within 7 days…
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
Among hospitalized adults treated with convalescent plasma, death within 30 days occurred in 115 of 515 (22%) patients in the group that received a product with a high titer of anti-spike IgG antibodies, 549 of 2006 (27%) patients in the medium-titer group, and 166 of 561 (30%) patients in the low-titer group. The relationship differed…
Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection in Hospital Health Care Workers
[Pre-print, not peer-reviewed] A prospective study of 801 healthcare workers (HCW) conducted from May-June 2020 found that SARS-CoV-2 incidence was highest in HCW working in COVID-19 patient care (13%), as compared with non-COVID-19 patient care (7%, HR=2.2) and not working in patient care (4%, HR=3.9). Within the group caring for COVID-19 patients, SARS-CoV-2 cumulative incidence…
Duration and Key Determinants of Infectious Virus Shedding in Hospitalized Patients with Coronavirus Disease-2019 (COVID-19)
A study of 129 hospitalized individuals who had been diagnosed with COVID-19 by RT-PCR detected infectious virus shedding by viral culture in 23 patients (18%), with infectious virus shedding for a median of 8 days after onset of symptoms. Multivariate analyses identified viral loads above 7 log10 RNA copies/mL as independently associated with isolation of infectious…
January 12, 2021
Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study
A nationwide cohort study in Sweden found that births occurring between April to May 2020 were not at elevated risk of preterm birth and stillbirth compared to births occurring during the same period in 2019. Excluding mothers with COVID-19 produced similar results. Among mothers in the cohort, the mean number of maternal healthcare visits (2.3)…
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