Alliance for Pandemic Preparedness

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November 3, 2020

Age-Specific Mortality and Immunity Patterns of SARS-CoV-2

Using age-specific COVID-19 death data and seroprevalence studies, the age distribution of deaths among those <65 years old was consistent across 45 countries. The infection fatality ratio (IFR) was estimated to be the lowest among children aged 5-9 years old (0.001%) and increased with age. The highest IFR was observed among those 80+ (8.3%). Mortality…


Association between Living with Children and Outcomes from COVID-19 an OpenSAFELY Cohort Study of 12 Million Adults in England

[Pre-print, not peer-reviewed] A population-based cohort study in England found that living with children was not associated with adverse COVID-19 related outcomes. Additionally, no consistent changes in risk were observed following school closure. Among 9 million adults ≤65 years old, living with children age 0-11 years was not associated with increased risk of recorded SARS-CoV-2…


SARS-CoV-2 Seroprevalence and Transmission Risk Factors among High-Risk Close Contacts: A Retrospective Cohort Study

A retrospective cohort study of all close contacts of confirmed COVID-19 cases in Singapore (n=7,770) found the attack rate among household contacts (5.9%) was higher compared to work contacts and social contacts (both 1.3%). Among contacts, close physical proximity (sharing a bedroom for household contacts and sharing a vehicle for work and social contacts) and…


November 2, 2020

Estimates of the Value of Life Lost from COVID-19 in Ohio

[Pre-print, not peer-reviewed] A study estimating the economic burden of deaths due to COVID-19 in Ohio using data from Public Health and the Social Security Administration found that there were 56,518 years of potential life lost, totaling an economic value of life lost of $13.60 billion. The value of life year lost was similar by…


Assessing the Risks of ‘Infodemics’ in Response to COVID-19 Epidemics

A study of Twitter messages from multiple countries early in the SARS-CoV-2 pandemic identified a co-occuring “Infodemic”: the rapid and widespread dissemination of misinformation or content from unreliable sources. Analysis of more than 100 million tweets indicated that waves of misinformation preceded the rise of COVID-19 infections, but content quickly shifted towards more credible information…


Development, Implementation, and Results from a COVID-19 Messaging Campaign to Promote Health Care Seeking Behaviors Among Community Clinic Patients

A study in North Carolina that delivered voice messages and texts encouraging patients (n=48,063) to call the regional operational call center line found that the odds of calling the line were higher among people from minority racial or ethnic groups (vs. white people), and among those who were uninsured or used Medicaid (vs. private insurance)….


The Effect of Eviction Moratoriums on the Transmission of SARS-CoV-2

[Pre-print, not peer-reviewed] Evictions led to significant increases in SARS-CoV-2 infections in a model simulating changes in housing patterns during the COVID-19 pandemic. In the model scenario for Philadelphia, a city with historically high eviction rates, the increase was especially pronounced as it considered a heterogenous city with frequent contacts between residents. The model indicated…


Quantifying the Impact of Public Health Protection Measures on the Spread of SARS-CoV-2

A study from France modeling the effectiveness of public health measures to slow the spread of SARS-CoV-2 (aside from strict lockdown) found that mask mandates and restricting access to public places such as bars reduced the number of new cases per day by 75% and delayed a peak in infections by about 2 months. However,…


Update: Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–Oct 3, 2020

Pregnant women with COVID-19 in the US were significantly more likely than nonpregnant women to be admitted to the ICU (aRR = 3.0), receive invasive mechanical ventilation (aRR = 2.9), and to die (aRR = 1.7) after adjusting for age, race/ethnicity, and underlying medical conditions. Although the absolute risks for severe outcomes were low, pregnant…


Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29 – October 14 , 2020

Among infants born to mothers with laboratory-confirmed SARS-CoV-2 infection (n=3,912), 12.9% of live births were preterm (<37 weeks), higher than the reported 10.2% in the general population in 2019. Perinatal infection was infrequent and occurred primarily among infants whose mother had SARS-CoV-2 infection identified within 1 week of delivery. The authors note that since most…



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