Alliance for Pandemic Preparedness

Article Summary


March 26, 2020

False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases.

This case study presents two false negative results of real-time RT-PCR which is regarded as the gold standard method for confirming SARS-CoV-2 infection. The study discusses using complementary approaches such as computed tomography (CT) in combination with rRT-PCR to achieve more reliable diagnosis.  Li et al. (Apr 2020). False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain…


Rapid Response to COVID-19: Health Informatics Support for Outbreak Management in an Academic Health System.

Reeves et al outline the design and implementation of EHR based rapid screening processes, laboratory testing, clinical decision support, reporting tools, and patient-facing technology related to COVID-19; and highlight the essential role of EHR in supporting clinical needs of a health system during this outbreak.  Reeves et al. (Mar 24, 2020). Rapid Response to COVID-19:…


An international comparison of the second derivative of COVID-19 deaths after implementation of social distancing measures.

This study suggests that early adoption of social distancing is more effective than delayed implementation, even of highly restrictive measures, implying that there may be a threshold of public health interventions after which a decline in death rates begins to occur.  This method may be helpful in planning for and monitoring the relaxation of social…


March 25, 2020

Characterizing occupations that cannot work from home: a means to identify susceptible worker groups during the COVID-19 pandemic.

Not all workers are employed in occupations which can be done from home, putting these individuals at increased risk of both SARS-CoV-2 exposure and job displacement.  Identifying these at-risk individuals may inform public health risk management and prioritize occupation sectors where additional protections are necessary. Baker (March 24, 2020). Characterizing occupations that cannot work from…


Chronology of COVID-19 cases on the Diamond Princess cruise ship and ethical considerations: a report from Japan.

This article summarizes the timeline of suspected and confirmed COVID-19 diagnosis, quarantine practices, and passenger release on the Diamond Princess cruise ship. The authors discuss critiques of specific government actions, ethical implications of barring ships with known outbreaks from docking, and the need for international collaboration. Nakazawa et al. (March 24, 2020). Chronology of COVID-19…


Analysis of psychological state and clinical psychological intervention model of patients with COVID-19

Anxiety and depression were both higher in COVID-19 patients at time of admission than in pneumonia patients or a healthy control group.  Anxiety and depression decreased in COVID-19 patients after one week of comprehensive psychological intervention.   Understanding the psychological state of patients with pneumonia, especially patients with COVID-19 can help clinicians systematically identify patients vulnerable…


High risk of infection caused posttraumatic stress symptoms in individuals with poor sleep quality: A study on influence of coronavirus disease (COVID-19) in China.

This study examines Wuhan-exposure, sleep quality, and posttraumatic stress symptoms (PTSS) in 2,027 Chinese residents.   The results indicate that supporting good quality sleep in individuals with high infectious risk may prevent PTSS.  Zhang et al. (March 24, 2020). High risk of infection caused posttraumatic stress symptoms in individuals with poor sleep quality: A study on…


The Impact of COVID-19 Epidemic Declaration on Psychological Consequences: A Study on Active Weibo Users.

Li et al review posts from 17,865 active users of Weibo, a Chinese social-media platform, and find an increase in negative emotions like anxiety, depression and indignation and sensitivity to social risks; as well as a decrease in positive emotions and life satisfaction after declaration of COVID-19 as an epidemic.  Using social media data may…


Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study.

Yu et al review findings from 7 pregnant COVID-19 patients in Wuhan, China with a focus on clinical features and obstetric and neonatal outcomes.   Clinical characteristics of these patients infected late in pregnancy were similar to those of non-pregnant adults, and maternal, fetal, and neonatal outcomes all appeared to be very good because of intensive…


Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.

In this cross-sectional study of 25 pediatric patients in Hubei province, China, the authors find that while children were still susceptible to COVID-19, the clinical presentations and outcomes were mostly favorable when compared to adults.  Extra attention during home-care and hospitalization treatment may be needed in the younger age-group that accounted for majority of the…



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