Alliance for Pandemic Preparedness

Article Summary


March 18, 2020

COVID-19 in a Long-Term Care Facility—King County, Washington, February 27 – March 9, 2020

McMichael et al describe the rapid spread of COVID-19 in a long-term care facility in Washington State, and calls for public heath interventions focused on surveillance, infection control and mitigation efforts in long-term care facilities to prevent introduction of COVID-19.  McMichael et al. (March 18, 2020). COVID-19 in a Long-Term Care Facility—King County, Washington, February…


Severe Outcomes Among Persons with Coronavirus Disease 2019 (COVID-19) —United States, February 12- March 16, 2020

This MMWR article provides a description of outcomes among patients with COVID-19 in the US that are similar to findings in China: fatality was highest in persons aged ≥85 (10% to 27%), followed by 3% to 11% among persons aged 65–84 years, 1% to 3% among persons aged 55-64 years, <1% among persons aged 20–54…


Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

This article demonstrates that the measures taken in hospitals in Hubei Province and Wuhan to increase medical resources such as more aided health workers, additional makeshift beds and acute care beds may have played a critical role in reducing mortality rates and improving recovery rates.  This may provide useful guidance to countries grappling with overwhelmed…


The effects of border control and quarantine measures on global spread of COVID-19

By developing a model that could provide a risk assessment of the global spread of COVID-19, the study demonstrates the importance of lowering the incidence at source regions and implementing strict control measures in the susceptible regions.   Hossain et al. (March 17, 2020). The effects of border control and quarantine measures on global spread of…


Impact of city and residential lockdowns on prevention and control of COVID-19

This article suggests that increasing medical resources, in particular hospital beds, and implementing residential lockdowns in addition to city lockdowns may result in more effective epidemic control.  Shao (March 17, 2020). Impact of city and residential lockdowns on prevention and control of COVID-19. Pre-print downloaded Mar 18 from https://doi.org/10.1101/2020.03.13.20035253 


If Containment is not possible, how do we minimize mortality for COVID-19 and other emerging infectious disease outbreaks?

If containment and social distancing measures cannot be sustained, it may be necessary to move towards herd immunity and allow some SARS-CoV-2 infections to occur, and prioritize interventions that protect vulnerable populations from getting infected.  The authors discuss how school closures potentially reduces infections in low risk groups while shifting the burden to the higher…


March 17, 2020

Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals

This study describes the ocular implications of human coronaviruses based on current evidence of animal coronaviruses and their associated ocular infections.  While the authors emphasize the need for more research to confirm SARS-CoV-2’s ability to infect ocular tissue and its pathogenic mechanisms, ophthalmologists and other HCWs should continue to use proper PPE to prevent possible…


COVID-19 in Children: Initial Characterization of the Pediatric Disease

The authors summarize key findings from a few studies that looked at COVID-19 in pediatric cases – 13% of confirmed cases were asymptomatic; 5% of symptomatic children had dyspnea or hypoxemia, and 0.6% progressed to acute respiratory distress syndrome or multi-organ system dysfunction; preschool-aged children and infants were more likely to have severe clinical manifestations…


Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients

Chen et al retrospectively reviewed 17 pregnant women with COVID-19 and found that both epidural and general anesthesia were safe and effective for pregnant women and newborns. The authors emphasize the need for proper patient transfer, medical staff access procedures, and effective biosafety precautions to protect medical staff from COVID-19.  Chen et al. (Mar 10,…


Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020

This report published by several public health and healthcare agencies in Korea summarizes the epidemiologic features of the 4,212 confirmed COVID-19 cases and provides snapshots of the COVID-19 outbreak in the Republic of Korea from Jan 19 through Mar 2, 2020.  Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious Diseases, et al. (Mar…



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