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March 11, 2020
Clinical Characteristics of 2019 Coronavirus Pneumonia (COVID-19): An Updated Systematic Review
Fang et al conducted a systematic review of clinical characteristics, radiology findings on chest CT scan and laboratory findings of 3,468 lab confirmed COVID-19 patients. This large patient-based systematic review provides useful information for physicians who manage COVID-19 patients. Fang et al. (Mar 10, 2020). Clinical Characteristics of 2019 Coronavirus Pneumonia (COVID-19): An Updated Systematic…
Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay
Researchers tested a new CRISPR-based DETECTR Lateral Flow Assay (CRISPR-Cas12) and found it to perform comparably to the US CDC SARS-CoV-2 real time RT-PCR assay. Broughton et al. (Mar 10, 2020). Rapid Detection of 2019 Novel Coronavirus SARS-CoV-2 Using a CRISPR-based DETECTR Lateral Flow Assay. Pre-print downloaded Mar 11 from https://doi.org/10.1101/2020.03.06.20032334
The impact of transmission control measures during the first 50 days of the COVID-19 epidemic in China
Tian et al report the impact of travel restriction and national emergency response in delaying the growth and limiting the size of COVID-19 epidemic in China. The Wuhan shutdown slowed the dispersal of infection to other cities by an estimated 2.9 days and averted hundreds of thousands of cases across China. The most effective interventions…
Estimation of incubation period distribution of COVID-19 using disease onset forward time: a novel cross-sectional and forward follow-up study
Qin et al conducted a longitudinal follow-up study of 1,211 asymptomatic individuals, who had travelled previously from Wuhan, until their symptoms developed. Findings suggest that about 10% of patients with COVID-19 may not develop symptoms until 14 days after infection. Further study of individuals with long incubation periods is warranted. Qin et al. (Mar 10,…
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
Chen et al retrospectively reviewed clinical and lab results for nine pregnant women with laboratory-confirmed COVID-19 pneumonia, for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. All the samples tested negative. Though limited in size, these findings reiterate findings from other recent studies suggesting that there is currently no…
Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1
There is new evidence indicating plausible fomite and aerosol transmission of COVID-19. Doremalen et al report that the stability of SARS-CoV-2 in the environment is similar to SARS-CoV-1. The agent can be detected in the aerosols up to 3 hours post aerosolization, up to 2 hours on copper, 24 hours on cardboard and up to…
March 10, 2020
Emergency management of the prevention and control of novel Coronavirus pneumonia in specialized branches of hospital
Ma et al discuss emergency management and prevention and control of COVID-19 in a hospital setting. They discuss changes in general, enforced ward and business management, leadership and hospital set up, and contingency plans. They report on personnel education and training, resource mobilization, three level prevention and control mechanisms, and environment and access management during…
Comparison of severe and non-severe COVID-19 pneumonia: review and meta-analysis
Ji et al reviewed literature to compare the difference between severe and non-severe COVID-19 pneumonia to identify common and symptoms associated with disease severity. Fever (89.2%), cough (67.2%), fatigue (43.6%) were common to severe and non-severe while polypnea/dyspnea, fever, and diarrhea were associated with severe disease. Ji et al. (Mar 9, 2020). Comparison of severe…
SARS-CoV-2 and COVID-19: facing the pandemic together as citizens and cardiovascular practitioners
Biondi-Zoccai et al describe the epidemiology, clinical signs, diagnosis, pharmaceutical and non-pharmaceutical interventions used, and clinical outcomes and associated complications of COVID-19 infection in Italy. The critical differential diagnoses for physicians is provided to proactively diagnose, risk-stratify, and manage patients with COVID-19 while not disregarding all other important cardiovascular conditions, which may well be worsened…
Of chloroquine and COVID-19
Touret and Lamballerie provide a commentary on studies that demonstrated benefits of chloroquine phosphate in inhibiting the exacerbation of pneumonia, improving lung imaging findings, promoting a virus negative conversion, and shortening the disease course. They however caution against drawing definitive conclusions without a clinical trial. Touret and Lamballerie (Mar 2, 2020). Of chloroquine and COVID-19….
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