Alliance for Pandemic Preparedness

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February 14, 2020

Three Emerging Coronaviruses in Two Decades: The Story of SARS, MERS, and Now COVID-19

SARS, MERS, and COVID-19 outbreaks and related clinical and public health response activities are compared and contrasted in this brief commentary.  Guarner (Feb 13, 2020). Three Emerging Coronaviruses in Two Decades: The Story of SARS, MERS, and Now COVID-19. Am J Clin Pathol. https://doi.org/10.1093/ajcp/aqaa029 


Straining the System: Novel Coronavirus (COVID-19) and Preparedness for Concomitant Disasters

This commentary outlines strengths of the U.S. public health system in responding to the COVID-19 outbreak.  Smith and Fraser (Feb 13, 2020). Straining the System: Novel Coronavirus (COVID-19) and Preparedness for Concomitant Disasters. AJPH. https://doi.org/10.2105/AJPH.2020.305618


Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak

Researchers discuss isolation, quarantine, and social distancing as successful tools used during the SARS outbreak and raise key questions that must be answered to determine if these measures would be effective in halting the current COVID-19 outbreak. Wilder-smith and Freedman (Feb 13, 2020). Isolation, quarantine, social distancing and community containment: pivotal role for old-style public…


Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients

Wax and Christian summarize key considerations for patient screening, environmental controls, personal protective equipment, resuscitation methods, and critical care unit operations planning, drawing on lessons learned from SARS response activities. Wax and Christian (Feb 12, 2020). Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anesth. https://doi.org/10.1007/s12630-020-01591-x 


Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections

Authors reviewed published data on the epidemiologic and clinical effects of SARS, MERS, and other coronaviruses on pregnant women, to evaluate the likelihood of poor maternal, fetal, and neonatal morbidity associated with COVID-19.  There is low risk of vertical transmission of coronavirus from mother to fetus, with no documented cases associated with SARS or MERS….


Potential Interventions for Novel Coronavirus in China: A Systemic Review

This systematic review provides recommendations on treatment protocols for COVID-19 patients, including assessing nutritional status, providing nutritional and immuno-enhancing interventions, coronavirus-specific treatments, antiviral medications, and specific considerations for pediatric patients and health care workers. Zhang and Liu (Feb 13, 2020). Potential Interventions for Novel Coronavirus in China: A Systemic Review. J of Med Virol. https://doi.org/10.1002/jmv.25707 


Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia

CT chest imaging for 21 patients with confirmed COVID-19 pneumonia were reviewed, with findings suggesting that lung abnormalities appear most severe approximately 10 days after symptom onset in patients without severe respiratory distress. Pan et al. (Feb 13, 2020). Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia….


February 13, 2020

The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus

Healthcare workers in Wuhan have been facing enormous pressure including a high rate of infection, inadequate protection from contamination, overwork and exhaustion, social isolation, lack of contact with their families, and negative interactions with their patients.  These issues are creating mental health issues of stress, depression, fear, denial and anger.   The government of Wuhan has…


Public responses to the novel 2019 coronavirus (2019‐nCoV) in Japan: mental health consequences and target populations

In Japan, economic and social impacts have been reported related to COVID-2019, including increased public anxiety, and some social stigmatization.  The authors believe that COVID-2019 adds to previous traumatic events in Japan involving frightening unseen agents.  These include the Sarin attack, pandemic H1N1, and radiation release from the Fukushima event.   It is anticipated that public…


Potentially highly potent drugs for 2019-nCoV

Researchers reviewed 1,465 FDA-approved drugs for potential efficacy in treating COVID-19, quantifying binding affinity and using machine learning methods. The highest scoring options were Bortezomib, Flurazepam, and Ponatinib. Nguyen et al. (Feb 5, 2020). Potentially highly potent drugs for 2019-nCoV. Pre-print downloaded Feb 13 from https://www.biorxiv.org/content/10.1101/2020.02.05.936013v1



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