Article Summary
April 6, 2021
Estimates and Projections of COVID-19 and Parental Death in the US
An estimated 37,300 children aged 0-17 years in the US had lost at least 1 parent due to COVID-19 by February 2021, of which roughly 3 in 4 are adolescents aged 10-17 years. Estimates were computed by taking current COVID-19 mortality estimates (479,000) and applying a bereavement multiplier (number of children parentally bereaved per COVID-19…
Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California
The 30-day incidence of venous thromboembolism (VTE) among SARS-CoV-2-positive individuals was not significantly increased compared to negative individuals in an outpatient setting (1.8 vs 2.2 cases per 1000) and in a post-hospitalization setting (1.0 vs 1.1 case per 1000) in a retrospective cohort study in Northern California (n=220,588) from February to August 2020. A significant…
The Contrasting Role of Nasopharyngeal Angiotensin Converting Enzyme 2 (ACE2) Transcription in SARS-CoV-2 Infection: A Cross-Sectional Study of People Tested for COVID-19 in British Columbia, Canada
In a cross-sectional study (n=424) of age and sex-matched SARS-CoV-2 positive and negative participants, mean relative expression of both the transmembrane and soluble isoforms of ACE2 was higher in negative participants despite ACE2 serving as the host receptor for SARS-CoV-2 cell entry. When analyzed together and adjusting for other factors, expression of transmembrane ACE2 was…
Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic
Peaks in the incidence of multisystem inflammatory syndrome in children (MIS-C) occurred 2-5 weeks after peaks in the incidence of COVID-19 and clinical manifestations of MIS-C varied by age. These findings were based on a cross-sectional study of 1,733 patients with MIS-C in the United States. Children age 0-4 had the lowest proportion of severe…
No Psychological Vaccination: Vaccine Hesitancy Is Associated with Negative Psychiatric Outcomes among Israelis Who Received COVID-19 Vaccination
Clinical depression, peri-traumatic distress, and clinical anxiety were associated with vaccine hesitancy in a cross-sectional study (n=254) of vaccinated participants aged ≥60 years in Israel. Palgi et al. (Mar 26, 2021). No Psychological Vaccination: Vaccine Hesitancy Is Associated with Negative Psychiatric Outcomes among Israelis Who Received COVID-19 Vaccination. Journal of Affective Disorders. https://doi.org/10.1016/j.jad.2021.03.064
COVID-19 MRNA Vaccines Drive Differential Fc-Functional Profiles in Pregnant Lactating and Non-Pregnant Women
[Pre-print, not peer-reviewed] The antibody response induced by mRNA vaccines (Moderna and Pfizer-BioNTech) after the first dose was lower among pregnant (n=84) and lactating (n=31) women compared to non-pregnant age-matched controls (n=16), but after the second dose no significant differences were observed. Differences in antibody response after the first dose related to lower antibody titers…
Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines
Local and systemic adverse reactions within 7 days of vaccination were more frequently self-reported by those who received the Moderna vaccine compared to those who received the Pfizer-BioNTech vaccines. Reactions were also more frequently reported after the second dose of these vaccines. These findings are based on V-Safe, a CDC surveillance system that included 3.6…
SLAMP A Rapid Fluorometric RT-LAMP Assay for Sensitive and Specific Detection of SARS-CoV-2 from Human Saliva
[Pre-print, not peer-reviewed] SLAMP, a novel RT-LAMP (reverse transcriptase loop-mediated isothermal amplification) assay applied to heat-inactivated saliva samples, demonstrated 91% sensitivity at 98% specificity compared to RT-PCR using nasopharyngeal swab samples among 243 individuals (65 SARS-COV-2 positive). Bikos et al. (Apr 5, 2021). SLAMP A Rapid Fluorometric RT-LAMP Assay for Sensitive and Specific Detection of SARS-CoV-2…
A New SARS-CoV-2 Lineage That Shares Mutations with Known Variants of Concern Is Rejected by Automated Sequence Repository Quality Control
[Pre-print, not peer-reviewed] A SARS-CoV-2 variant (named B.1.x) may be an emerging lineage that has been poorly recognized due to a deletion mutation that causes the submission of its sequence to be rejected by automated sequence repository quality control in genome databases such as GISAID and Genbank. The variant, which contains a deletion in the…
Genomic Surveillance of Nevada Patients Revealed Prevalence of Unique SARS-CoV-2 Variants Bearing Mutations in the RdRp Gene
A novel SARS-CoV-2 mutation (P323 F/L) in the non-structural protein ORF was identified using a genomic surveillance sample of 200 high quality sequences obtained in Nevada from March to June 2020. Phylogenetic reconstruction of the samples cross-referenced to a subsample of sequences in the Nextstrain global genome database show that variants with the mutation P323L…
Previous page Next page