Alliance for Pandemic Preparedness

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December 23, 2020

Changes in Elder Abuse Risk Factors Reported by Caregivers of Older Adults During the COVID‐19 Pandemic

During the  COVID-19 pandemic, the caregivers of elders report experiencing adverse experiences previously established as risk factors for elder abuse. Persons responsible for the care of community-dwelling adults over the age of 60 report increasing financial hardship, greater worry about finances, heavier use of alcohol, increasing feelings of social isolation and loneliness, and greater physical,…


Comparison of Knowledge and Information-Seeking Behavior After General COVID-19 Public Health Messages and Messages Tailored for Black and Latinx Communities

In a randomized trial, participants who identified as Black and Latinx who were assigned to watch public health video messages recorded by a physician of the same race/ethnicity were less likely have knowledge gaps regarding COVID-19 when compared to those who were received messages delivered by race-discordant physicians. Participants were presented videos regarding the symptoms,…


Clinical Outcomes, Costs, and Cost-Effectiveness of Strategies for Adults Experiencing Sheltered Homelessness During the COVID-19 Pandemic

In a modeling study that simulated adults living in shelters, daily symptom screening with PCR testing of individuals who had positive symptom screening and use of alternative care sites for COVID-19 management were associated with substantially reduced new cases and costs compared with other strategies. When community transmission surges, adding universal testing every two weeks…


Changes in UK Hospital Mortality in the First Wave of COVID-19 the ISARIC WHO Clinical Characterisation Protocol Prospective Multicentre Observational Cohort Study

[pre-print; not peer-reviewed] Among people recently admitted to the hospital with COVID-19 in the United Kingdom, there was a 19% reduction in the odds of mortality compared to the first wave of the epidemic. After adjusting for demographics, comorbidities, and illness severity, the authors compared the mortality observed during a four-week interval in March to…


Epidemiology of COVID-19 Infection in Young Children under Five Years: A Systematic Review and Meta-Analysis

A meta-analysis of laboratory confirmed COVID-19 in children under 5 years of age determined that children were frequently prescribed antibiotics and that the majority of the reported cases were children less than one year old. Bhuiyan et al. identified 65 studies of epidemiological and clinical characteristics of lab-confirmed COVID-19 infections in 1,214 children under age…


Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic

COVID-19 mortality rates in the US declined among hospitalized patients over the first few months of the pandemic with better outcomes associated with low community prevalence of COVID-19, according to a retrospective cohort analysis. The authors constructed a cohort of 38,517 adults from a deidentified administrative database in patients admitted with COVID-19 from January 1…


Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic

A prospective cohort study of 127 pregnant women found inefficient transplacental transfer of maternal SARS-CoV-2 specific antibodies and no evidence for prolonged viremia in either maternal or fetal circulation. No detectable viremia in maternal or cord blood was identified in 64 participants diagnosed with COVID-19 and no SARS-CoV-2 RNA was detected in 88 tested placentas….


Evaluating the Efficacy of COVID-19 Vaccines

Using dual or triple primary endpoints that include SARS-CoV-2 infection, symptomatic infection and severe COVID-19 could speed up characterization and licensure of vaccines for SARS-CoV-2, according to models of placebo controlled-vaccine trials. The authors suggest that dual or triple primary endpoints could speed up the discovery, characterization, and licensure of effective vaccines by creating data…


Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection

Choe et al. used four commercial immunoassays to measure SARS-CoV-2 antibodies from seven participants with asymptomatic SARS-CoV-2 infection and 51 patients with mildly symptomatic infections eight months after they tested positive by rt-PCR. For three of the four immunoassays used, seropositivity rates were high (69% to 91%). Antibody positivity differed significantly between the immunoassay methods,…


The Advisory Committee on Immunization Practices’ Updated Interim Recommendation for Allocation of COVID-19 Vaccine — United States, December 2020

The Advisory Committee on Immunization Practices (ACIP) now recommends that the COVID-19 vaccine be offered to people over the age of 75 and non-health care frontline workers in Phase 1B of the vaccine rollout. This is an update to recent vaccine allocation recommendations that suggested vaccinating health care personnel and long-term care facility residents against…



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