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Tag: candidate
October 12, 2020
Diagnostic Accuracy of FDA Authorized Serology Tests to Detect SARS-CoV-2 Antibodies A Systematic Review and Meta-Analysis
[Pre-print, not peer reviewed]A systematic review and meta-analysis of the diagnostic accuracy of seven different FDA-authorized tests for SARS-CoV-2 antibodies found that the pooled sensitivity was 87% and the pooled specificity was nearly 100%. Sensitivity increased with increased time between symptom onset and sample collection: at ≤ 7 days, sensitivity was 44%, for 8-14 days,…
Air and Surface Contamination in Non-Health Care Settings among 641 Environmental Specimens of 39 COVID-19 Cases
A study of SARS-CoV-2 contamination of environmental surfaces and air found that SARS-CoV-2 may be present on environmental surfaces for several days, especially in bathrooms. 641 specimens were collected from homes, hotels, public areas, cars, and pets that were potentially in contact with 39 individuals positive for SARS-CoV-2 in China. All positive specimens, based on…
Global Projections of Potential Lives Saved from COVID-19 through Universal Mask Use
[Pre-print, not peer reviewed] An IHME analysis found that universal mask use could lead to a reduction of 815,600 (95% UI 430,600 – 1,491,000) deaths from COVID-19 globally between August 26th 2020 and January 1st 2021. The analysis used meta-regression of 40 studies measuring the impact of mask use on respiratory viral infections, as well…
September 30, 2020
The Potential Contribution of Face Coverings to the Control of SARS-CoV-2 Transmission in Schools and Broader Society in the UK a Modelling Study
[Pre-print, not peer-reviewed] A modeling study shows that adoption of masks in secondary schools and community settings under current test-trace-isolate (TTI) levels could reduce the size of a second wave in the UK but not prevent it. Under current tracing levels, and at effective mask coverage of 30%, 46% of those with symptomatic infection would…
COVID-19 among People Experiencing Homelessness in England: A Modelling Study
A modeling study found that continuing measures to prevent SARS-CoV-2 infection among people experiencing homelessness would result in a small projected number of cases and deaths (1754 infections, 31 deaths) in the context of a second wave of SARS-CoV-2 infection in the general population (June 2020 to January 2021). However, in a scenario with no…
Comparison of Infection Control Strategies to Reduce COVID-19 Outbreaks in Homeless Shelters in the United States a Simulation Study
[Pre-print, not peer-reviewed] A microsimulation model calibrated to PCR data from outbreaks in 5 homeless shelters found that while infection control strategies can prevent outbreaks in low-risk settings, they may be unlikely to do so in high-risk settings. The model found that in shelters with low (R0 = 1.5), moderate (R0 = 2.9), and high…
Maternal Mental Health and Coping during the COVID‐19 Lockdown in the UK: Data from the COVID‐19 New Mum Study
Among surveyed women living in the UK with an infant aged ≤12 months (n=1,329), a majority reported feeling down (56%), lonely (59%), irritable (62%), and worried (71%) since the beginning of lockdown, but 70% felt able to cope. Having support with her own health, contacting infant support groups, and higher gestational age of the infant…
Angiotensin-Converting Enzyme 2 (ACE2) Levels in Relation to Risk Factors for COVID-19 in Two Large Cohorts of Patients with Atrial Fibrillation
Male sex, cardiovascular disease, diabetes, and biomarker indicators of biological aging were associated with higher levels of soluble angiotensin-converting enzyme 2 (sACE2) among two international cohorts of elderly patients with atrial fibrillation. Higher levels of sACE2 could reflect a higher cellular expression of ACE2, a cellular receptor by which SARS-CoV-2 enters human cells, and thus…
Risk Factors, Presentation, and Course of Coronavirus Disease 2019 in a Large, Academic Long-Term Care Facility
Nearly half (46%) of the 146 out of 389 residents of a long-term care facility who were diagnosed with COVID-19 were asymptomatic at the time of diagnosis, emphasizing the importance of universal testing rather than symptom-based testing to control outbreaks. Anorexia and delirium where the most common symptoms during the course of illness. Male sex…
Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection
Among a cohort of hospitalized patients with COVID-19 in the US (n=1685), the risk of death remained significantly greater among patients with a psychiatric disorder after controlling for demographic characteristics, other medical comorbidities, and hospital location. Li et al. (Sept 30, 2020). Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus…
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