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Tag: clinical characteristics
November 12, 2020
‘Long-COVID’: A Cross-Sectional Study of Persisting Symptoms, Biomarker and Imaging Abnormalities Following Hospitalisation for COVID-19
Among 384 patients in London followed for an average of 54 days post-discharge from COVID-19 hospitalization, 53% reported persistent breathlessness, 34% cough, 69% fatigue, and 14.6% depression. 38% of chest radiographs remained abnormal and 9% showed signs of worsening. Mandal et al. (Nov 10, 2020). ‘Long-COVID’: A Cross-Sectional Study of Persisting Symptoms, Biomarker and Imaging…
Sixty-Day Outcomes Among Patients Hospitalized With COVID-19
Among 1,648 hospitalized COVID-19 patients in Michigan, 1250 (75.8%) survived and were discharged between March 16 and July 1, with a majority returning home. By 60 days post-discharge, an additional 84 patients died, bringing the overall mortality rate to 29.2% (63.5% among those admitted to ICU). An additional 189 (15.1%) patients were rehospitalized. Among the…
November 10, 2020
Characteristics and Outcomes of Neonatal SARS-CoV-2 Infection in the UK: A Prospective National Cohort Study Using Active Surveillance
A national prospective study in the UK found low incidence (5.6 per 10,000 live births) of neonatal SARS-CoV-2 infection. Of the 66 babies identified with SARS-CoV-2 during the study period, 17 (26%) babies were born to mothers with known perinatal SARS-CoV-2 infection, and only 2 (3%) were considered to have possible vertically acquired infection. The…
November 9, 2020
Characteristics of Hospitalized COVID-19 Patients Discharged and Experiencing Same-Hospital Readmission — United States, March–August 2020
Among 106,543 patients discharged after hospitalization for COVID-19 in the US between March–July 2020, 9,504 (9%) experienced at least one readmission to the same hospital within 2 months of discharge, including 1,667 (2%) who were readmitted more than once. The median interval from discharge to first readmission was 8 days (IQR 3–20 days). Risk factors for…
November 6, 2020
Viral RNA Level, Serum Antibody Responses, and Transmission Risk in Recovered COVID-19 Patients with Recurrent Positive SARS-CoV-2 RNA Test Results: A Population-Based Observational Cohort Study
Intermittent excretion of low levels of SARS-CoV-2 RNA after hospital discharge was not associated with either secondary transmission or worsening clinical disease. A population-based observational study of patients in China who had clinically recovered from SARS-CoV-2 and satisfied criteria for discharge including two negative PCR tests were then re-tested as outpatients. 479 patients were found…
November 5, 2020
Clinical Characteristics of Re-Positive COVID-19 Patients in Huangshi, China: A Retrospective Cohort Study
In an observational retrospective cohort study in Huangshi, China, 23 out of 368 recovered COVID-19 patients quarantined for 14 days post-discharge retested positive for SARS-CoV-2. Retesting positivity was associated with a higher ratio of lymphocytes on admission and presence of comorbidities, while negatively associated with a lower peak temperature during hospitalization and arbidol treatment. Zhou…
Clinical Characteristics of Recovered COVID-19 Patients with Re-Detectable Positive RNA Test
Among 262 patients with COVID-19, 14.5% were found to be re-detectable positive (RP) after at least 14 days of follow up. Most RP patients were young (under 60), initially had mild to moderate illness, and had earlier RNA-negative conversion from illness onset (less than 3 weeks) than non-RP patients. All RP patients were readmitted for…
November 4, 2020
Frequency and Profile of Objective Cognitive Deficits in Hospitalized Patients Recovering from COVID-19
[Preprint, not peer-reviewed] Cognitive impairments were found frequently in patients recovering from severe COVID-19 in an inpatient rehabilitation facility. A cross-sectional study tested 57 patients with a mean age of 65 years using standard measures of memory and executive function and found that 81% had cognitive impairment, with deficits most common in working memory (55%),…
November 3, 2020
Symptoms at Presentation for Patients Admitted to Hospital with Covid-19 Results from the ISARIC Prospective Multinational Observational Study
[Pre-print, not peer-reviewed] Results from a large prospective cohort (n=60,161 symptomatic patients with confirmed COVID-19 from 43 countries) found that the most sensitive case definition, which was met by 92% of the cohort, was one or more of cough, shortness of breath, fever, muscle pains or sort throat. These symptoms were more frequent among patients…
Systematic Review and Meta‐analysis of Factors Associated with Re‐positive Viral RNA after Recovery from COVID‐19
A systematic review of 9 studies found that compared to recovered COVID-19 patients who did not experience a recurrent positive PCR test, recovered COVID-19 patients who experienced a recurrent positive test had shorter hospital stay (14.5 vs 15.5 days) and were more likely to have fatigue symptoms, and to test positive for IgM and IgG….
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