Alliance for Pandemic Preparedness

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Tag: health care setting


October 30, 2020

COVID-19 Test Result Turnaround Time for Residents and Staff in US Nursing Homes

A study of SARS-CoV-2 antigen test turnaround times among Medicare-certified skilled nursing facilities (SNFs) found that although testing delays improved over time in the study period, few SNF across the US received test results in less than 24 hours. In early September, test turnaround time was less than 1 day for 6% of SNFs testing…


October 23, 2020

SARS CoV-2 Surveillance and Exposure in the Perioperative Setting with Universal Testing and Personal Protective Equipment (PPE) Policies

Universal PCR-based surveillance testing for SARS-CoV-2 before surgeries or procedures at a tertiary care center in New York City identified 65 patients (0.6%) were positive out of 11,540 patients tested. The proportion of tests that were positivity peaked at 4.3% and fell below 0.3% after April 2020. Three of the 65 individuals who tested positive…


October 22, 2020

Incidence of Health Care–Associated COVID-19 During Universal Testing of Medical and Surgical Admissions in a Large US Health System

Eight cases of possible incident SARS-CoV-2 were observed during hospitalization or within 14 days post-discharge among 2,992 patients who tested negative on admission to UW Medicine (Washington) hospitals between April 2 and May 14. Further review determined 1 to 6 cases as potential hospital-acquired infections, corresponding to a relatively low incidence of 0.8 to 5…


October 21, 2020

Characteristics and Outcomes of Clinically Diagnosed RT-PCR Swab Negative COVID-19 a Retrospective Cohort Study

[Pre-print, not peer-reviewed] Among 456 patients with clinical suspicion of COVID-19 and an initial negative PCR result for SARS-COV-2 by nasopharyngeal swab (March 1 to April 12, 2020), 94 (20%) were later confirmed as clinical COVID-19 cases. Among these, 47 (50%) tested positive with repeat PCR testing and 41 (44%) continued to have negative PCR…


October 16, 2020

Heterogeneity in Testing, Diagnosis and Outcome in SARS-CoV-2 Infection across Outbreak Settings in the Greater Toronto Area, Canada: An Observational Study

A population-based prospective cohort study of residents of long-term care homes, people living in shelters, and members of the general population in Toronto, Canada found that residents of long-term care homes were 2.4 times more likely to test positive for SARS-CoV-2 than the general population and those who received a diagnosis of COVID-19 were 1.4…


October 13, 2020

Inter-Region Transfers for Pandemic Surges

A modeling study evaluating potential hospital bed shortages during COVID-19 surges found that inter-region transfers could alleviate regional bed shortfalls. In the worst-case scenarios in the study, national bed shortfalls ranged from 669 to 58,562 inpatient beds and 3,208 to 31,190 ICU beds. Average transfer distances that would be required to address these shortfalls ranged…


October 12, 2020

Prevalence and Longevity of SARS-CoV-2 Antibodies in Healthcare Workers A Single Center Study

[Pre-print, not peer reviewed]A cross-sectional study to determine the prevalence and longevity of SARS-CoV-2 antibodies in healthcare workers and first responders in California showed that antibody prevalence was 0.9% at the start of the study and 2.6% at 8-week follow-up among healthcare workers, and 5.3% and 4.4%, respectively, among first responders (between May and August,…


Clinical Impact of Molecular Point-of-Care Testing for Suspected COVID-19 in Hospital (COV-19POC): A Prospective, Interventional, Non-Randomised, Controlled Study

Point-of-care testing for SARS-CoV-2 was associated with large reductions in time to results compared with centralized laboratory PCR testing in a prospective, interventional, non-randomized study of molecular point-of-care testing in the UK. 39% of adult patients in the point-of-care testing group and 28% in the control group tested positive for SARS-CoV-2 infection using nose and…


October 9, 2020

SARS-CoV-2 Exposure, Symptoms and Seroprevalence in Healthcare Workers in Sweden

An assessment of the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms, and occupational exposure to SARS-CoV-2 among 2,149 healthcare workers at a hospital in Sweden found that 19% had IgG antibodies against SARS-CoV-2, which was higher than the regional seroprevalence during that time period. Seroprevalence was associated with a loss of smell (OR=28.4), loss of taste…


October 8, 2020

Extended Use or Re-Use of Single-Use Surgical Masks and Filtering Facepiece Respirators during COVID-19: A Rapid Systematic Review

A rapid systematic review found limited evidence of protective efficacy when surgical masks and N95 respirators are either reused or had extended use in frontline healthcare settings. Despite limited evidence, the review highlighted vaporized hydrogen peroxide and ultraviolet irradiation as the most promising reprocessing methods. The level of detail and consistency varied across the 6…



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