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December 15, 2020
Assessment of the Risk of SARS-CoV-2 Reinfection in an Intense Re-Exposure Setting
Among 101,349 lab-confirmed SARS-CoV-2 cases in Qatar, the risk of reinfection was estimated to be 0.02%, with a reinfection incidence rate of 0.36 per 10,000 person-weeks. Out of 243 patients with at least one positive swab ≥45 days from the first positive swab, 54 (22%) had strong or good evidence for reinfection. Viral genome sequencing…
Asynchrony Between Individual and Government Actions Accounts for Disproportionate Impact of COVID-19 on Vulnerable Communities
Mobility data across 1,124 US counties show that individuals began to socially distance at a median of 5 days (IQR=3-8) after 10 cumulative confirmed COVID-19 cases in their state, but at a median of 12 days (IQR=8-17) before state governments issued stay-at-home orders (SAHOs). Using SAHO dates as a proxy for social distancing accounts for…
November 4, 2020
Beyond the 405 and the 5: Geographic Variations and Factors Associated with SARS-CoV-2 Positivity Rates in Los Angeles County
In Los Angeles, geographic factors associated with an increased rate of SARS-CoV2 diagnosis included a higher proportion of Latino/Latina residents, higher rates of poverty and higher household density. The analysis was conducted using a spatial analysis of the health department data from the period of 1 March and 30 June 2020, with a total of…
They’re Dying in the Suburbs COVID-19 Cases and Deaths by Geography in Louisiana (USA)
[Preprint, not peer-reviewed] The epicenter of the Louisiana COVID-19 epidemic has varied temporally, beginning in the urban core of New Orleans and then moving to suburban/rural areas. Using census tract- and parish-level data in Louisiana, Schnake-Mahl et al. reported that the incidence (73 cases per 10,000) and mortality rate (5.6 deaths per 10,000) of COVID-19…
COVID-19 Active Surveillance Simulation Case Study – Health and Economic Impacts of Active Surveillance in a School Environment
A simulation study of a school environment concluded that daily testing can assist with maintenance of a low infection rate. The authors concluded that a reasonable daily test percentage (6%-10% with social distancing and mask wearing, or 8-10% without mitigation procedures) among the student population can achieve a low infection rate (≤10%). Saad et al….
Frequency and Profile of Objective Cognitive Deficits in Hospitalized Patients Recovering from COVID-19
[Preprint, not peer-reviewed] Cognitive impairments were found frequently in patients recovering from severe COVID-19 in an inpatient rehabilitation facility. A cross-sectional study tested 57 patients with a mean age of 65 years using standard measures of memory and executive function and found that 81% had cognitive impairment, with deficits most common in working memory (55%),…
SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study
A prospective cohort study in North Carolina found that 77% of children and adolescents living with a close household contact infected with SARS-CoOV-2 had a positive SARS-COV2 PCR test. Hispanic ethnicity (OR=1.5) and having an infected sibling close contact (OR=1.7) were associated with increased infection risk. One or more symptoms were reported by 70% of…
Association of COVID-19 RT-QPCR Test False-Negative Rate with Patient Age Sex and Time since Diagnosis
[Preprint, not peer-reviewed] A study using electronic health records in Israel reported that the 11% of PCR tests for SARS-CoV-2 were negative with 0-5 days of clinical diagnosis among patients who had at least one positive PCR test (n= 521,696). Patients who were female (vs. male: OR=1.7) and patients who were younger (10 vs. 40…
SARS-CoV-2 Detection by Nasal Strips a Superior Tool for Surveillance of Pediatric Populations
In pediatric patients, the use of small strips inserted into each nostril was shown to have a sensitivity of 94% and specificity of 100% for the detection of SARS-CoV-2 when compared to pooled nasopharyngeal swab and throat swab samples. Viral loads of SARS-CoV-2 RNA were similar between paired nasal strip samples and nasal swab samples….
Avoiding versus Contracting COVID-19 On the Effectiveness of Social Distancing at the Level of the Individual
[Preprint, not peer-reviewed] A participant’s behavior during behavioral simulation of social distancing behaviors was associated with the risk of subsequently contracting COVID-19, whereas self-report of these behaviors was not. Results from a survey among 2,120 US residents determined that an individual’s performance in a simulator intended to assess physical positioning was associated with lower risk…
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