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September 30, 2020

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers

Daily administration of hydroxychloroquine to hospital-based healthcare workers as pre-exposure prophylaxis against SARS-CoV-2 infection did not change infection risk between participants receiving hydroxychloroquine vs placebo (6.3% vs 6.6%, p>0.99) in this randomized, double-blind, placebo-controlled trial (n=132). The trial was terminated early due to futility and may have been underpowered to detect clinically important differences. Abella…

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