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Tag: testing
January 13, 2021
Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-through Community Testing Site in Massachusetts
[Pre-print, not peer-reviewed] An evaluation of the Abbott BinaxNOW COVID-19 Ag Card in a drive-through community testing site in Massachusetts using anterior nasal swab RT-PCR for clinical testing found that BinaxNOW had very high specificity in both adults and children (100% for both) and very high sensitivity in newly symptomatic adults (96.5% within 7 days…
January 12, 2021
The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs
A systematic review and meta-analysis (37 studies with 7,332 paired nasopharyngeal swab and saliva samples) found that while saliva samples had slightly lower sensitivity to detect SARS-CoV-2, they could be more cost-effective. Against a reference standard of a positive result on either sample, saliva sensitivity was 7.9% lower than nasopharyngeal swab sensitivity among persons without…
January 8, 2021
Assessment of Day-7 Postexposure Testing of Asymptomatic Contacts of COVID-19 Patients to Evaluate Early Release from Quarantine — Vermont, May–November 2020
Following a policy change to shorten the duration of quarantine for people exposed to SARS-CoV-2 who remained asymptomatic and tested negative by PCR at day 7, an analysis did not identify any contacts who tested positive within the subsequent week. Among 940 contacts of people with COVID-19 who tested negative seven days after exposure, 154…
January 5, 2021
Performance of At-Home Self-Collected Saliva and Nasal-Oropharyngeal Swabs in the Surveillance of COVID-19
A study assessing the performance of at-home self-collected saliva and nasal-oropharyngeal (NOP) swabs for SARS-CoV-2 testing (RT-PCR) among patients who met the criteria for suspected COVID-19 identified 70 out of 201 patients with positive samples from saliva, NOP, or both swabs. 37/70 (53%) were positive in both swabs, 18/70 (26%) were positive in saliva swabs…
Rapid Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Detention Facility, Louisiana, USA, May–June, 2020
A cohort investigation in a detention facility in Louisiana identified rapid transmission and high cumulative incidence of SARS-CoV-2 infection among quarantined inmates. Among 143 persons in 6 quarantined dormitories tested using serial nasal swabs, 53 were PCR positive at initial testing and an additional 58 persons tested positive at later time points (cumulative incidence 78%)….
January 4, 2021
Longitudinal Testing for Respiratory and Gastrointestinal Shedding of SARS-CoV-2 in Day Care Centres in Hesse, Germany
A longitudinal study of children (n=859, age 3 months – 8 years) and staff (n=376) from daycare centers in Germany conducted from June-September 2020 found that detection of either respiratory or gastrointestinal shedding of SARS-CoV-2 RNA was rare in the context of limited community activity and with facility-based infection prevention measures. Of 7,366 buccal mucosa…
Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses — Wisconsin, September–October 2020
Use of SARS-CoV-2 antigen testing on two university campuses had a positive predictive value of 33% and a negative predictive value of 99%. Compared to RT-PCR testing, the Sofia antigen test had a sensitivity of 80.0% and specificity of 98.9% among symptomatic people. Accuracy was lower (sensitivity 41.2% and specificity 98.4%) when used for screening…
December 30, 2020
Field Performance and Public Health Response Using the BinaxNOW Rapid SARS-CoV-2 Antigen Detection Assay during Community-Based Testing
Among 3,302 persons tested for SARS-CoV-2 by BinaxNOW Rapid SARS-CoV-2 antigen detection assay in a community setting with 7.2% prevalence, rapid assay sensitivity was 100%, 98.5%, and 89% using RT-PCR Ct thresholds of 30, 35 and none, respectively. The assay maintained high sensitivity performance across ages and those with and without symptoms. Assay specificity was…
December 28, 2020
Patterns of SARS-CoV-2 testing preferences in a national cohort in the United States
[pre-print; not peer-reviewed] Based on results from a discrete choice experiment (n=4,793), the uptake for testing for SARS-CoV-2 was predicted to increase by 82% to 98% if less invasive testing (saliva specimen type), dual testing (both viral and antibody tests), and at home testing scenarios were offered in addition to standard testing scenarios. Romo et…
December 23, 2020
Multiplex Assays for the Identification of Serological Signatures of SARS-CoV-2 Infection: An Antibody-Based Diagnostic and Machine Learning Study
Testing for multiple biomarkers, as opposed to testing for a single antibody, increased the sensitivity of correctly identifying past SARS-CoV-2 infection. A multiplex serological assay was used to measure IgG and IgM antibody responses to seven SARS-CoV-2-specific antigens, two seasonal coronavirus antigens, and three non-coronavirus antigens. Antibodies were measured in serum samples collected up to…
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