Result for
Tag: testing
May 21, 2021
COVID-19 Testing to Sustain In-Person Instruction and Extracurricular Activities in High Schools — Utah, November 2020–March 2021
An evaluation of two high school COVID-19 testing programs implemented in Utah to support continuation of in-person instruction and extracurricular activities found that the programs saved an estimated 109,952 in-person instruction student-days and supported continuation of extracurricular activities. One program implemented SARS-CoV-2 testing every 14 days for participation in extracurricular activities, and the other implemented…
Mutation-Specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation
An evaluation of a novel multiplex, mutation-specific PCR-based assay on 247 SARS-CoV-2 positive samples found 100% concordance for strain typing of variants B.1.1.7 and P.1 compared to whole genome sequencing methods. This method detects five variants of concern and three variants of interest, including the B.1.526.1 variant emerging in the Eastern US. The assay can…
May 19, 2021
Evaluation of Six Different Rapid Methods for Nucleic Acid Detection of SARS-COV-2 Virus
In a comparison of 6 rapid antigen tests against RT-PCR for SARS-CoV-2 detection in 4,981 participants, AQ-TOP and Genechecker had the highest sensitivity (98% and 95%) and positive predictive value (96% and 95%), followed by the sensitivity of Abbott ID NOW (95%) and Cobas Liat (95%). The performance of the Atila iAMP COVID-19 test was…
May 17, 2021
Seven-Day COVID-19 Quarantine May Be Too Short Assessing Post-Quarantine Transmission Risk in Four University Cohorts
[Pre-print, not peer-reviewed] A cohort study conducted at four US universities between September 2020 and February 2021 found that a seven-day quarantine period may not be sufficient to maintain a 5% transmission risk threshold, and that risk depends on the strictness of quarantine measures. The study compared “strict quarantine”, which included designated housing with private…
May 14, 2021
Community-Based Testing for SARS-CoV-2 — Chicago, Illinois, May–November 2020
A community-based SARS-CoV-2 testing (CBT) program in Chicago found that persons tested at CBT sites (N=250,000) were more likely to have SARS-CoV-2 infection compared to persons tested in other settings. Persons who were tested at the CBT sites were also more likely to be <40 years of age, Hispanic, and live in economically marginalized zip…
Diagnostic Performance of an Antigen Test with RT-PCR for the Detection of SARS-CoV-2 in a Hospital Setting — Los Angeles County, California, June–August 2020
An evaluation of the rapid Quidel Sofia 2 SARS Antigen FIA test in patients hospitalized with COVID-19 at a large, tertiary medical center in Los Angeles found a lower sensitivity in symptomatic (72%) and asymptomatic (61%) patients compared to RT-PCR. Specificity of the Antigen test was >98% in both symptomatic and asymptomatic patients. The authors…
May 13, 2021
Persisting Salivary IgG against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys
Anti-SARS-CoV-2 spike IgG antibodies were detectable in >85% of saliva samples obtained from 74 mostly mild COVID-19 patients up to 9 months-post symptom onset. Salivary IgG responses were highly correlated with anti-spike IgG. In contrast, anti-nucleocapsid IgG was much lower in samples collected 3 months post symptom onset. In a separate cohort of 147 asymptomatic…
May 11, 2021
SARS-CoV-2 Rapid Antigen Test: High Sensitivity to Detect Infectious Virus
Overall sensitivity of the Panbio rapid antigen test was 71.8% and the sensitivity of the Orient Gene rapid antigen tests was 79.5% for the detection of 156 PCR-confirmed SARS-CoV-2 positive samples. Tested against a panel of PCR-confirmed negative samples, the Panbio test achieved 100% specificity (130 of 130 negative samples) and the Orient Gene test…
A New SARS-CoV-2 Variant Poorly Detected by RT-PCR on Nasopharyngeal Samples with High Lethality
[Pre-print, not peer-reviewed] Patients confirmed by viral sequencing to be infected with a novel SARS-CoV-2 variant first described in France (assigned lineage B.1.616) (n=34) were less likely to test positive on their first PCR test (15% vs 97%) and more likely to die within 28 days (44% vs 16%) compared to patients infected with variants…
May 10, 2021
Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum
A study comparing the performance of three commercial immunoassays to detect SARS-CoV-2 IgA and IgG antibodies (Euroimmun SARS-COV-2 IgA/IgG, Mikrogen recomWell SARS-CoV-2 IgA/IgG, and SERION ELISA agile SARS-CoV-2 IgA/IgG) and three rapid lateral flow tests (Abbott Panbio COVID-19 IgG/IgM, NADAL COVID-19 IgG/IgM, and Cleartest Corona 2019-nCOV IgG/IgM) to a gold standard plaque-reduction neutralization test (PRNT50) found that the…
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