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Tag: vaccination
April 8, 2021
Neutralizing Response against Variants after SARS-CoV-2 Infection and One Dose of BNT162b2
A single dose of the Pfizer-BioNTech vaccine substantially increased neutralizing activity against SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 among healthcare workers (HCWs) previously infected with SARS-CoV-2 (n=6). Serum samples from each HCW were obtained 1-12 weeks after natural infection, immediately before vaccination, and 1-2 weeks after vaccination and were tested using a microneutralization assay containing…
April 6, 2021
Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines
Local and systemic adverse reactions within 7 days of vaccination were more frequently self-reported by those who received the Moderna vaccine compared to those who received the Pfizer-BioNTech vaccines. Reactions were also more frequently reported after the second dose of these vaccines. These findings are based on V-Safe, a CDC surveillance system that included 3.6…
April 5, 2021
Dynamic Prioritization of COVID-19 Vaccines When Social Distancing Is Limited for Essential Workers
A modeling study assessing vaccine allocation in the US across priority groups by age and essential worker status determined that prioritizing essential workers could potentially avert between 20,000 (when nonpharmaceutical interventions are strong) and 300,000 (when these interventions are weak) deaths. The authors suggest their findings indicate that optimal vaccine allocation may change over time,…
April 1, 2021
Willingness to Receive a COVID-19 Vaccination Among Incarcerated or Detained Persons in Correctional and Detention Facilities — Four States, September–December 2020
The COVID-19 vaccination refusal rate was 45% among 5,110 surveyed residents of three prisons and 13 jails across four states during September to December 2020 (all three prisons and 10 jails in Washington State). The most common reason for vaccination refusal was distrust of health care, correctional, or government personnel or institutions (20%). 10% of…
March 31, 2021
Initial Report of Decreased SARS-CoV-2 Viral Load after Inoculation with the BNT162b2 Vaccine
In a real-world analysis of data from individuals in Israel who tested positive for SARS-CoV-2 after receiving the first dose of the Pfizer-BioNTech vaccination (n=4,938), viral load was substantially lower (2.8 to 4.5-fold lower) for infections occurring 12-37 days after the first dose compared to individuals who had not been vaccinated. Cycle of threshold (Ct)…
March 30, 2021
SARS-CoV-2 Infection Risk among Unvaccinated Is Negatively Associated with Community-Level Vaccination Rates
[Pre-print, not peer-reviewed] Increases in the proportion of individuals aged 16-50 years receiving the first dose of the Pfizer-BioNTech vaccine were followed by declines in the SARS-CoV-2 positivity rate among a bystander unvaccinated cohort of people under 16 years old in 223 geographically defined communities in Israel. The proportion of vaccinated individuals and SARS-CoV-2 positivity…
Association of Race/Ethnicity With Likeliness of COVID-19 Vaccine Uptake Among Health Workers and the General Population in the San Francisco Bay Area
Black, Latinx, and Asian employees of three large medical centers in San Francisco had lower odds of reporting that they were likely to get vaccinated against COVID-19 compared to white employees in a cross-sectional study conducted from November 2020 to January 2021 (n=1,803). Compared to white respondents, Black, Asian and Latinx had 50%, 63%, and…
March 25, 2021
COVID-19 Infection Risk amongst 14104 Vaccinated Care Home Residents A National Observational Longitudinal Cohort Study in Wales United Kingdom December 2020 to March 2021
[Pre-print, not peer-reviewed] Only 1% of over 14,000 nursing home residents in the UK who have received the first dose of either the Pfizer-BioNTech or Oxford-AstraZeneca vaccines reported a positive SARS-CoV-2 PCR test in an observational study from December 2020 to March 2021. 90% of infections occurred within 28 days of the first dose. At…
March 15, 2021
COVID-19 Vaccine Second-Dose Completion and Interval Between First and Second Doses Among Vaccinated Persons — United States, December 14, 2020-February 14, 2021
Vaccination data reported to CDC indicate that among people who received the first dose of either the Moderna or Pfizer/BioNTech vaccines as of February 14, 2021, and for whom enough time had elapsed to receive the second dose, 88.0% had completed the series and 8.6% had not received the second dose. Among all people who…
A Rapid Review of COVID-19 Vaccine Prioritization in the U.S. Alignment between Federal Guidance and State Practice
[Pre-print, not peer-reviewed] A study assessing variability in vaccine priority groups between state and federal guidance found that while state plans largely prioritized healthcare workers and residents of long-term care facilities (consistent with federal guidelines), essential workers were often excluded from state priority plans. Of 37 states that included frontline essential workers, 12 assigned them…
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