Alliance for Pandemic Preparedness

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March 11, 2021

Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 MRNA Vaccine

After a single dose of either the Pfizer-BioNTech or Modernan vaccine, US vaccinees with prior SARS-CoV-2 infection (n=43) had antibody titers 10-45 times as high as those of vaccinees without prior SARS-CoV-2 infection (n=67), according to interim results of a longitudinal study. While titers of those with prior infection did not increase after the second…

March 10, 2021

The Plasmablast Response to SARS-CoV-2 MRNA Vaccination Is Dominated by Non-Neutralizing Antibodies That Target Both the NTD and the RBD

[Pre-print, not peer-reviewed] A study of vaccine-induced polyclonal antibodies and monoclonal antibodies (mAbs) from subjects who received SARS-CoV-2 mRNA vaccines found that polyclonal antibody responses were robust and comparable to or exceeded those observed after natural infection. However, most vaccine-induced mAbs did not demonstrate neutralizing activity. Neutralizing activity of N-terminal domain (NTD) mAbs, but not…


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