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Topic: Clinical Characteristics and Health Care Setting
January 20, 2021
Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic
Periods of increased ICU demand were associated with increased COVID-19 mortality in a cohort of 8,516 patients admitted to Veteran’s hospitals. Compared to periods of low ICU demand (<25%), the adjusted hazard ratio for all-cause mortality was 0.99 for patients treated when COVID-19 ICU demand was 25%-50%, 1.19 when demand was 50%-75%, and 1.94 when…
Follow‐up of SARS‐CoV‐2 Positive Subgroup from the Asymptomatic Novel CORonavirus INfection (ACORN) Study
22% of asymptomatic participants with positive SARS-CoV-2 nasopharyngeal swabs developed symptoms within 14 days, according to results from the Asymptomatic novel CORonavirus iNfection (ACORN). Symptoms developed in 19 out of 86 participants a median of 6 days after the initial positive test result, the most frequently reported of which were fatigue or muscle aches (11%),…
January 15, 2021
Circulating Mitochondrial DNA Is an Early Indicator of Severe Illness and Mortality from COVID-19
Elevated mitochondrial DNA levels measured within 24 hours of presentation were associated with mortality, ICU admission, intubation, vasopressor use, and renal replacement therapy in patients hospitalized with COVID-19. These associations were maintained after adjustment for age, sex, and comorbidities. Circulating mitochondrial DNA levels demonstrate similar or improved sensitivity over clinically established measurements for assessing potential…
Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago
A study conducted among hospital workers in Illinois in May and June 2020 (n=6510) found that support service workers (10.4%), medical assistants (10.1%), and nurses (7.6%) had significantly higher prevalence of COVID-19 seropositivity than administrators (3.3%). Among participants who had a family member in their home who tested positive for COVID-19 (n=93), 54% were seropositive….
Clinical Outcomes From COVID-19 Following Use of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers Among Patients with Hypertension in South Korea: A Nationwide Study
Recorded use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) in the 30 days preceding their COVID-19 diagnosis was not associated with all-cause mortality or respiratory events in a cohort of 682 people with hypertension who tested positive for COVID-19. ACEI/ARB use was associated with lower rates of use of mechanical ventilation,…
Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19
Women hospitalized for childbirth with confirmed COVID-19 (n=6,380) were younger, more often Black and/or Hispanic, and more often had diabetes or obesity than women without COVID-19. Although in-hospital mortality was low, it was significantly higher in the women with COVID-19 than in those without COVID-19 (141 vs 5 deaths per 100,000 women). The women with…
The Epidemiological and Radiographical Characteristics of Asymptomatic Infections with the Novel Coronavirus (COVID-19): A Systematic Review and Meta-Analysis
A systematic review and meta-analysis (104 studies, n=20,152 participants) found that 13.3% of individuals with SARS-CoV-2 infection were asymptomatic, though there was substantial variation between studies (I2=95%). Children were more likely to be asymptomatic than adults (32% vs. 10%). More than 47% of asymptomatic individuals who had chest imaging had abnormal lung findings. Chen et…
January 14, 2021
Bacterial but No SARS-CoV-2 Contamination after Terminal Disinfection of Tertiary Care Intensive Care Units Treating COVID-19 Patients
After disinfection of two tertiary COVID-19 ICUs in Switzerland, no SARS-CoV-2 RNA was detected among 86 swabs sampled from defined locations. 90 swabs sampled in parallel in the same locations revealed low contamination with gram-negative bacteria, particularly in sinks and siphons. One ICU was disinfected with Kohrsolin 1% and dry mist hydrogen peroxide, while the…
Sleep Apnoea Is a Risk Factor for Severe COVID-19
A nationwide retrospective study in Finland (n=260,405) found that while obstructive sleep apnea (OSA) was not associated with a COVID-19 diagnosis, OSA was associated with COVID-19 hospitalization (aOR=2.93) after adjusting for age, sex, BMI, and comorbidities. A separate meta-analysis including other published studies found a pooled OR estimate of 1.55. Strausz et al. (Jan 12,…
January 13, 2021
Epidemiology of COVID-19 in Mexico, Symptomatic Profiles and Presymptomatic People
Epidemiologic data collected between June and September 2020 from more than 480,000 outpatients with RT-PCR-confirmed SARS-CoV-2 infection in Mexico indicated that there was a high incidence of COVID-19 among working-age people (41%), with young adults (aged 20-40 years) the most affected. More than half of the people who tested positive (53%) had contact with SARS-CoV-2…
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